The digestion and absorption characteristics of human milk phospholipid analogs: a combination study between in vitro and in vivo

• DOI: 10.1039/d3fo02779a
• Publication Date: 2023-11-15T08:30:58Z
• Authors: Jiaxin Shen; Yanping Wu; Teng Wei; Yangzheng He; Xiaoru Liu; Zeyuan Deng; Jing Li
• Keywords: Digestion; Lipid digestion

Phospholipids play a crucial role in the growth and neurodevelopment of infants. Currently, soybean phospholipids (SPLs) are common phospholipid component most infant formulas (IFs), which, however, shows an obvious difference with (PL) composition human milk fat. Therefore, present study, analogs (HMPAs) were prepared by mimicking PE, PC, PI, PS, SM breast major fatty acids (C16:0, C18:0, C18:1, C18:2), their digestion absorption characteristics explored using vitro mice models. The HMPA contained 26.48% 24.64% 36.19% SM, 6.35% 6.32% 40.51% C16:0, 17.02% 29.19% 13.26% C18:2, showing different digestive properties relative to SPL. There was little effect on physical chemical under gastric conditions. hydrolysis degree, release rate, average particle size decreasing rate significantly higher than that SPL during intestine (P < 0.05), better process In terms model, had degree intestinal tract. Based area curve (AUC) analysis serum acids, it found despite being absorbed at slower SPL, more summary, preferred these obtained results might provide theoretical basis for development utilization IF.