Whole grain germinated brown rice intake modulates the gut microbiota and alleviates hypertriglyceridemia and hypercholesterolemia in high fat diet-fed mice

• DOI: 10.1039/d3fo03288d
• Publication Date: 2023-11-14T03:21:40Z
• Authors: Shuai Han; Xiuxiu Wu; Lingfeng Zhu; Han Lu; Xuke Ling; Yi Luo; Zuomin Hu; Yaping Zhou; Yiping Tang; Feijun Luo
• Keywords: Brown rice; Gut–brain axis

Hyperlipidemia is a common clinical disorder of lipid metabolism in modern society and considered to be one the major risk factors leading cardiovascular-related diseases. Germinated brown rice (GBR) typical whole grain food. The lipid-lowering effect GBR has received increasing attention, but its mechanism action not fully understood. gut microbiota been proposed as novel target for treatment hyperlipidemia. aim this study was investigate effects on high-fat diet (HFD)-fed C57BL/6J mice. hyperlipidemia evaluated by measuring blood levels pathological examination. detected 16S rRNA sequencing, protein mRNA expression involved cholesterol were western blotting RT-qPCR find potential correlations. results showed that supplementation could effectively reduce TC, TG, LDL-C HDL-C serum alleviate excessive accumulation fat droplets caused HFD. Moreover, intervention improved HFD-fed via diversity microbiota, reducing Firmicutes/Bacteroidetes ratio, improving barrier damage. In addition, inhibit endogenous synthesis promote transport excretion. These findings suggest may competitive candidate development functional foods prevent abnormal metabolism.