Comparison of the effectiveness of probiotic supplementation in glucose metabolism, lipid profile, inflammation and oxidative stress in pregnant women

• DOI: 10.1039/d3fo04456d
• Publication Date: 2024-02-21T09:00:41Z
• Authors: Yi-Ke Li; Chen-Lin Xiao; Huan Ren; Wen-Ru Li; Zhen Guo; Jian-Quan Luo
• Keywords: Lipid Profile; Carbohydrate Metabolism

Objective: The optimal probiotic supplementation in pregnant women has not been thoroughly evaluated. By employing a network meta-analysis (NMA) approach, we compared the effectiveness of different strategies for women. Methods: A comprehensive search across multiple databases was performed to identify studies comparing efficacy supplements with each other or control (placebo) among Results: This NMA, including 32 studies, systematically evaluated 6 supplement strategies: Lactobacillus, Lacticaseibacillus rhamnosus and Bifidobacterium (LRB), Lactobacillus acidophilus (LABB), acidophilus, casei, bifidum (LLB), multi-combination four probiotics (MP1), six more (MP2). Among these strategies, LLB, MP1, MP2 all contain LABB. NMA findings showed that MP1 most effective reducing fasting blood sugar (FBS) (surface under cumulative ranking curve [SUCRA]: 80.5%). In addition, efficacious lowering homeostasis model assessment insulin resistance (HOMA-IR) (SUCRA: 89.1%). LABB ranked as decreasing low-density lipoprotein cholesterol (LDLC) 95.5%), total (TC) high-sensitivity C-reactive protein (hs-CRP) 94.8%). Moreover, LLB raising antioxidant capacity (TAC) 98.5%). Conclusion: Multi-combination strains, especially those containing LABB, may be than single strain glycolipid metabolism, inflammation, oxidative stress