Multi-lineage heart-chip models drug cardiotoxicity and enhances maturation of human stem cell-derived cardiovascular cells

• DOI: 10.1039/d3lc00745f
• Publication Date: 2024-01-22T16:19:38Z
• Authors: Maedeh Mozneb; Amelia Jenkins; Samuel Sances; Stephany Pohlman; Michael J. Workman; Dylan West; Briana Ondatje; Kareem El-Ghazawi; Amanda Woodbury; Veronica J. Garcia; Shachi Patel; Madelyn Arzt; Felipe Dezem; Alex H. Laperle; V. Alexandra Moser; Ritchie Ho; Nur Yucer; Jasmine Plummer; Robert J. Barrett; Clive N. Svendsen; Arun Sharma
• Keywords: 0301 basic medicine; 03 medical and health sciences

Cardiovascular toxicity causes adverse drug reactions and may lead to drug removal from the pharmaceutical market. We have developed a cardiac organ-chip using pluripotent stem cells to enhance cell maturity and model drug cardiotoxicity.