piRNAs in the human retina and retinal pigment epithelium reveal a potential role in intracellular trafficking and oxidative stress

• DOI: 10.1039/d3mo00122a
• Publication Date: 2024-01-15T15:21:00Z
• Authors: Muthuramalingam K...; Suganya Sivagurun...; T. Sayamsmruti Panda; Nagesh Srikakulam; Reety Arora; Lamiya Dohadwala; Basant K. Tiwary; Sudha Rani Sadras; Jayamuruga Pandia...; Gopal Pandi; Subbulakshmi Chid...
• Keywords: 0301 basic medicine; RNA-Binding Proteins; Retinal Pigment Epithelium; Retina; Cell Line; Oxidative Stress; MicroRNAs; 03 medical and health sciences; Piwi-Interacting RNA; Argonaute Proteins; Humans; RNA, Long Noncoding; RNA, Small Interfering

piRNAs profiled from human retina/RPE share seed sequence homology with miRNAs and lncRNAs. They play regulatory roles in intracellular transport, circadian rhythm, oxidative stress, and retinal neurodegeneration.