A ROS storm generating nanocomposite for enhanced chemodynamic therapy through H2O2 self-supply, GSH depletion and calcium overload

• DOI: 10.1039/d3nr06422k
• Publication Date: 2024-04-03T00:41:24Z
• Authors: Yong Li; Jing Wang; Tao Zhu; Ying Zhan; Xiaoli Tang; Jianying Xi; Xiaohui Zhu; Yong Zhang; Jinliang Liu
• Keywords: Mice, Inbred BALB C; Hydroxyl Radical; Hydrogen Peroxide; Glutathione; 01 natural sciences; Nanocomposites; 0104 chemical sciences; Mice; Cell Line, Tumor; Neoplasms; Tumor Microenvironment; Animals; Humans; Calcium; Reactive Oxygen Species; Buthionine Sulfoximine; Copper

A CaO2-based multifunctional nanocomposite which possesses H2O2 self-supplying, GSH depletion and calcium overload properties was prepared, the nanocomposite can enhance the efficacy of CDT and accelerate tumor apoptosis.