A general Fe-catalysed azidation of iododifluoroketones and its utilization for the synthesis of gem-difluoromethylenated triazoles

• DOI: 10.1039/d3qo02088f
• Publication Date: 2024-02-07T11:41:34Z
• Authors: Xia Wang; Shixun Liu; Shibo Xu; Shiguang Wu; Jingjing Wu; Fanhong Wu
• Keywords: 01 natural sciences; 0104 chemical sciences

An iron-catalysed radical azidation of iododifluoroketones with TMSN 3 was developed under mild conditions to provide a concise synthesis α-difluoroalkylazides, which could be transformed into the useful N–CF 2 triazoles via CuAAC reaction.