Disulfide radical anion as a super-reductant in biology and photoredox chemistry

• DOI: 10.1039/d3sc01867a
• Publication Date: 2023-05-17T18:01:50Z
• Authors: Qilei Zhu; Cyrille Costentin; JoAnne Stubbe; Daniel G. Nocera
• Keywords: [CHIM.THEO]Chemical Sciences/Theoretical and/or physical chemistry; Chemistry; 540; 3. Good health

Peak and half-peak potentials poorly approximate standard reduction potentials (E0), especially for compounds that dissociate upon reduction. We determine E0 of disulfides and show cysteine disulfide radical anion to be a powerful biological reductant.