Structurally divergent enantioselective synthesis of benzofuran fused azocine derivatives and spiro-cyclopentanone benzofurans enabled by sequential catalysis

• DOI: 10.1039/d3sc03239f
• Publication Date: 2023-09-07T06:24:15Z
• Authors: Rupkumar Khuntia; Sanat Kumar Mahap...; Lisa Roy; Subhas Chandra Pan
• Keywords: Chemistry; 3. Good health

We have developed a divergent approach for the catalytic asymmetric synthesis of skeletally different benzofuran fused azocine derivatives and spiro-cyclopentanone benzofurans. The methodology involves sequential catalysis: chiral H-bonding catalysis and Lewis base catalysis.