Melamine-cored glucosides for membrane protein solubilization and stabilization: importance of water-mediated intermolecular hydrogen bonding in detergent performance

• DOI: 10.1039/d3sc03543c
• Publication Date: 2023-10-23T08:41:15Z
• Authors: Lubna Ghani; Seonghoon Kim; Muhammad Ehsan; Baoliang Lan; Ida H. Poulsen; Chandra Dev; Satoshi Katsube; Bernadette Byrne; Lan Guan; Claus J. Loland; Xiangyu Liu; Wonpil Im; Pil Seok Chae
• Keywords: 570; Chemistry; 540

A melamine-based glucoside, MG-C11, has the ability to form a dynamic hydrogen-bonding network between detergent molecules, responsible for the markedly enhanced efficacy for GPCR stabilization compared to LMNG and previously developed TTG-C11.