Parallel kinetic resolution of aziridines via chiral phosphoric acid-catalyzed apparent hydrolytic ring-opening

• DOI: 10.1039/d3sc03899h
• Publication Date: 2023-10-12T14:40:55Z
• Authors: Juan Liu; Yi-Ying Du; Yu-Shi He; Yan Liang; Shang-Zhong Liu; Yi-Yi Li; Yi-Ming Cao

An intriguing chiral phosphoric acid-catalyzed asymmetric hydrolytic ring-opening of racemic aziridines via regiodivergent PKR is presented, providing an efficient approach for the construction of chiral β-amino alcohols.