Mn2+-induced structural flexibility enhances the entire catalytic cycle and the cleavage of mismatches in prokaryotic argonaute proteins

• DOI: 10.1039/d3sc06221j
• Publication Date: 2024-03-14T11:40:48Z
• Authors: Lirong Zheng; Bingxin Zhou; Yu Yang; Bing Zan; Bozitao Zhong; Banghao Wu; Yan Feng; Qian Liu; Liang Hong
• Keywords: Argonaute; Cleavage (geology)

Prokaryotic Argonaute (pAgo) proteins, a class of DNA/RNA-guided programmable endonucleases, have been extensively utilized in nucleic acid-based biosensors.