Hydroxyapatite nanoparticles induced calcium overload-initiated cancer cell-specific apoptosis through inhibition of PMCA and activation of calpain

• DOI: 10.1039/d3tb00542a
• Publication Date: 2023-06-20T02:02:17Z
• Authors: Xiulin Dong; Chunyu Zang; Yi Sun; Shuiquan Zhang; Changsheng Liu; Jiangchao Qian
• Keywords: Durapatite; Calpain; Neoplasms; Nanoparticles; Calcium; Apoptosis; 3. Good health

Intracellular degradation of HAPNs and inhibition of PMCA activity jointly contributed to calcium overload in tumor cells, which then activated calpain-mediated mitochondrial apoptosis pathways, resulting in cancer cell-specific toxicity.