Hydroxyapatite nanoparticles induced calcium overload-initiated cancer cell-specific apoptosis through inhibition of PMCA and activation of calpain

Durapatite Calpain Neoplasms Nanoparticles Calcium Apoptosis 3. Good health
DOI: 10.1039/d3tb00542a Publication Date: 2023-06-20T02:02:17Z
ABSTRACT
Intracellular degradation of HAPNs and inhibition PMCA activity jointly contributed to calcium overload in tumor cells, which then activated calpain-mediated mitochondrial apoptosis pathways, resulting cancer cell-specific toxicity.
SUPPLEMENTAL MATERIAL
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