Radiation responsive PROTAC nanoparticles for tumor-specific proteolysis enhanced radiotherapy

• DOI: 10.1039/d3tb03046f
• Publication Date: 2024-02-21T04:01:01Z
• Authors: Mengxia Xu; Yuyang Yun; Changjun Li; Yiling Ruan; Osamu Muraoka; Weijia Xie; Xiaolian Sun
• Keywords: Proteolysis; Degradation

Proteolysis targeting chimeras (PROTACs) is a promising strategy for cancer therapy. However, the always-on bioactivity of PROTACs may lead to non-target toxicity, which restricts their antitumor performance. Here, we developed an X-ray radiation responsive PROTAC nanomicelle (RCNprotac) by covalently conjugating reported small molecule (MZ1) hydrophilic PEG