Advanced piperazine-containing inhibitors target microbial β-glucuronidases linked to gut toxicity

0301 basic medicine Chemistry 03 medical and health sciences
DOI: 10.1039/d4cb00058g Publication Date: 2024-07-16T08:31:25Z
ABSTRACT
Leveraging medicinal chemistry and structural biology to optimize microbial GUS inhibitors to UNC10206581, which displays potent L1 and FMN GUS activity – the structural subclasses linked to GI toxicity via small molecule glucuronide reactivation.
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