Oxalic acid as a dual C1 surrogate for heterogeneous palladium-catalyzed tandem four-component quinazolinone synthesis

• DOI: 10.1039/d4cc01084a
• Publication Date: 2024-05-01T09:41:33Z
• Authors: Sheetal; Poonam Sharma; Ashish Kumar; Navneet Sharma; Kousik Giri; Pralay Das
• Keywords: Quinazolinone; Tandem; Oxalic Acid; Cascade reaction; Component (thermodynamics)

Herein, a heterogeneous Pd/C-catalyzed direct one-step four-component double carbonylative approach for cascade synthesis of 2-aryl quinazolinones has been reported the first time starting from 2-iodoaniline derivatives and aryl iodides. The given reaction involves simultaneous implementation two different gaseous surrogates