Photo-ejected ligands hyperpolarized by parahydrogen in reversible exchange

• DOI: 10.1039/d4cc06807f
• Publication Date: 2025-02-20T14:21:01Z
• Authors: Emily E. Brown; Rielly J. Harrison; Dmytro Havrylyuk; Stephen J. McBride; Edith C. Glazer; Felix N. Castellano; Thomas Theis

Hyperpolarization derived from signal amplification by reversible exchange (SABRE) is valued for its relative simplicity among hyperpolarization approaches. Here, we demonstrate that photoejection of the ligands pyridazine and pyrazine prodrug Ru(II) polypyridyl complexes offers a new modality activating SABRE hyperpolarization, achieving enhancements over 3200-fold.