Anticancer activity and mechanism studies of photoactivated iridium(iii) complexes toward lung cancer A549 cells

• DOI: 10.1039/d4dt01677g
• Publication Date: 2024-08-14T13:21:16Z
• Authors: Lin Zhou; Jiongbang Li; Ju Chen; Xin Yao; Xiandong Zeng; Yunjun Liu; Yi Wang; Xiuzhen Wang
• Keywords: Membrane Potential, Mitochondrial; Lung Neoplasms; Photosensitizing Agents; Light; Molecular Structure; Cell Survival; Antineoplastic Agents; Apoptosis; Iridium; Photochemical Processes; 01 natural sciences; 0104 chemical sciences; Coordination Complexes; A549 Cells; Cell Movement; Humans; Calcium; Drug Screening Assays, Antitumor; Reactive Oxygen Species; Cell Proliferation

Three new iridium( iii ) complexes were synthesized and characterized. The in vitro anticancer activity of the against A549 cells was investigated, exhibited high efficacy upon irradiation.