The dose-dependent mechanism behind the protective effect of lentinan against acute alcoholic liver injury via proliferating intestinal probiotics

• DOI: 10.1039/d4fo02256d
• Publication Date: 2024-09-10T06:01:41Z
• Authors: Fangjia Zhao; Min Li; Mingyue Luo; Meng Zhang; Yahong Yuan; Haili Niu; Tianli Yue
• Keywords: Male; Mice, Inbred C57BL; Mice; Oxidative Stress; Disease Models, Animal; Lentinan; Liver; Dose-Response Relationship, Drug; Probiotics; Animals; Protective Agents; Liver Diseases, Alcoholic; Gastrointestinal Microbiome

Different LNT doses promoted the proliferation of probiotics with different functions, which prevented liver function impairment, oxidative stress, and inflammation caused by acute excessive alcohol consumption.