A metal–organic cage-derived cascade antioxidant nanozyme to mitigate renal ischemia-reperfusion injury

• DOI: 10.1039/d4nr00742e
• Publication Date: 2024-04-04T08:24:41Z
• Authors: Cheng Huang; Yucen Deng; Rongze Ma; Hucheng Ge; Fuzhong Gong; Jinghui Yang; Xinyuan Zhu; Youfu Wang
• Keywords: 02 engineering and technology; 0210 nano-technology

In the field of contemporary medicine, inflammation has emerged as a significant concern in global public health. Among current anti-inflammatory strategies, nanozymes possess distinctive advantages and demonstrate unexpected efficacy combating inflammation. However, indeterminate structures limited enzyme-like activity exhibited by most developed impede their clinical translation therapeutic effectiveness. this paper, we nanozyme derived from well-defined metal-organic cage (MOC). The oxidized MOC (MOC-O), containing pyridine nitrogen oxide moieties, effective cascade superoxide dismutase (SOD) catalase (CAT)-like activities for scavenging reactive oxygen species (ROS). This ROS ability was confirmed through flow cytometry analysis using DCFH-DA hypoxia/reoxygenation (H/R) model, where MOC-O significantly alleviated oxidative stress. Furthermore, administration resulted preserved renal function during ischemia-reperfusion (I/R) injury due to downregulated stress levels reduced cell apoptosis.