Determination of absolute intramolecular distances in proteins using anomalous X-ray scattering interferometry

• DOI: 10.1039/d4nr03375b
• Publication Date: 2024-12-09T08:40:53Z
• Authors: Samuel Stubhan; Anna V. Baptist; Caroline Körösy; Alessandra Narducci; Gustavo Gabriel M...; Nicolas Wendler; Aidin Lak; Michael Sztucki; Thorben Cordes; Jan Lipfert
• Keywords: 0301 basic medicine; Chemistry; 0303 health sciences; 03 medical and health sciences; ddc:530

We establish high-resolution (<1 Å) intramolecular distance measurements in proteins using pairs of small (1.4 nm diameter) gold nanoparticle labels and anomalous small-angle X-ray scattering as a read out.