Use of ionic liquids in amidation reactions for proteolysis targeting chimera synthesis

• DOI: 10.1039/d4ob00304g
• Publication Date: 2024-04-11T08:10:50Z
• Authors: Michela Eleuteri; Jenny Desantis; Gabriele Cruciani; Raimondo Germani; Laura Goracci
• Keywords: Proteolysis; Chimera (genetics)

Selective degradation of disease-causing proteins using proteolysis targeting chimeras (PROTACs) has gained great attention, thanks to its several advantages over traditional therapeutic modalities.