Water-assisted cascade synthesis of trifluoromethylated dipyridodiazepinone analogues: in vitro and in silico antibacterial studies

• DOI: 10.1039/d4ob00828f
• Publication Date: 2024-07-19T17:21:05Z
• Authors: Shivangi Jaiswal; Dharma Kishore; Annu Bhardwaj; Khushboo Bhardwaj; Shruti Richa; Smita Jain; Jaya Dwivedi; Swapnil Sharma
• Keywords: 01 natural sciences; 0104 chemical sciences

A water-assisted cascade reaction has been described to afford a new series of trifluoromethylated dipyridiodiazepinone derivatives as antibacterial agents. This methodology has a broad substrate scope with minimal waste generation.