Anticancer evaluations of iodoquinazoline substituted with allyl and/or benzyl as dual inhibitors of EGFRWT and EGFRT790M: design, synthesis, ADMET and molecular docking

• DOI: 10.1039/d4ra00502c
• Publication Date: 2024-03-06T14:52:01Z
• Authors: Ahmed K. B. Aljohani; Khaled El-Adl; Basmah Almohaywi; Omar M. Alatawi; Marwa Alsulaimany; Ahmed El-morsy; Sara A. Almadani; Hussam Y. Alharbi; Majed S. Aljohani; Felemban Athary A...; Hanan E. M. Osman; Samy Mohamady
• Keywords: 0301 basic medicine; Chemistry; 0104 chemical sciences

Fifteen new iodoquinazoline derivatives, 5a,b to 18, are reported in this study and their anticancer evaluation as dual inhibitors of EGFRWT and EGFRT790M.