A green bio-organic catalyst (taurine) promoted one-pot synthesis of (R/S)-2-thioxo-3,4-dihydropyrimidine(TDHPM)-5-carboxanilides: chiral investigations using circular dichroism and validation by computational approaches

• DOI: 10.1039/d4ra01391c
• Publication Date: 2024-03-19T14:27:29Z
• Authors: Mehul P. Parmar; Disha P. Vala; Savan S. Bhalodiya; Dipti B. Upadhyay; Chirag D. Patel; Subham G. Patel; Srinivasa R. Gand...; Althaf H. Shaik; Amy Dunne Miller; Joaquina Nogales; Sourav Banerjee; José M. Padrón; Nasser Amri; Nagesh Kumar Kand...; Hitendra M. Patel
• Keywords: Chemistry; 540; 01 natural sciences; 0104 chemical sciences

Twenty-three new derivatives of ( R / S )-TDHPM-5-carboxanilide have been synthesized with up to 99% yield. All racemates were separated using chiral HPLC (Prep LC) which provided 99.99% purity. AC was determined circular dichroism spectra.