Biosynthesis of the bacterial antibiotic 3,7-dihydroxytropolone through enzymatic salvaging of catabolic shunt products

• DOI: 10.1039/d4sc01715c
• Publication Date: 2024-04-24T07:41:06Z
• Authors: Lars Höing; Sven T. Sowa; Marina Toplak; Jakob K. Reinhardt; Roman Jakob; Timm Maier; Markus A. Lill; Robin Teufel
• Keywords: Catabolism

The biosynthesis of the bacterial antibiotic dihydroxytropolone was reconstituted in vitro starting from a catabolic shunt product. involved key flavoprotein monooxygenase TrlE further structurally and mechanistically characterized.