Thiol-selective native grafting from polymerization for the generation of protein–polymer conjugates

• DOI: 10.1039/d4sc04818k
• Publication Date: 2024-09-18T07:25:38Z
• Authors: Melina I. Feldhof; Sandro Sperzel; Lorand Bonda; Susanne Boye; Adam B. Braunschweig; Ulla I. M. Gerlin...; Laura Hartmann
• Keywords: Thiol; Conjugate

Protein-polymer conjugates combine properties of biopolymers and synthetic polymers, such as specific bioactivity increased stability, with great benefits for various applications from catalysis to biomedicine. Furthermore, polymer conjugation can mimic important posttranslational modifications proteins glycosylation. There are typically two approaches create protein-polymer conjugates: the protein is functionalized in advance an initiator a