Peptide–DNA conjugate-assisted DNA cyclization for highly efficient and sensitive detection of furin

• DOI: 10.1039/d5ay00370a
• Publication Date: 2025-04-22T06:20:22Z
• Authors: Minghui Wang; Cuifei Chen; Keqin Ying; Lingjun Sha; Deqi Kuang; Yue Huang; Jie Yang; Tingting Yin

In this work, the proximity effect of the engineered peptide-DNA conjugate (PDC) is harnessed to induce DNA cyclization, enabling highly efficient and sensitive detection of furin.