Synthetic Chemistry Enabling the Discovery and Development of a Series of Pyrazoles as HPK1 Inhibitors

• DOI: 10.1039/d5md00309a
• Publication Date: 2025-05-27T13:00:42Z
• Authors: Anthony J. Metrano; Lucas Morrill; Gayathri Bommakanti; Robert Casella; Steve Cook; Randolph A Escobar; Kathryn Giblin; Eric Gosselin; Tyler Grebe; Niresh Hariparsad; Rachel Howells; Gillian Lamont; Deanna A. Mele; Alexander Pflug; Theresa Proia; Hadi Rezaei; Magdalena Richter; Ryan Richards; Maryann San Martin; Marianne Schimpl; Alwin G. Schuller; Li Sha; James E. Sheppeck II; Kun Song; Haoran Tang; David J. Wagner; Jianyan Wang; Allan Wu; Dedong Wu; Ye Wu; Kevin Xu; Minwei Ye; Jason D. Shields; Neil Patrick Grim...

Hematopoietic Progenitor Kinase 1 (HPK1) is a negative regulator of T-cell signaling. Inhibition HPK1 with small molecules has been shown to reinvigorate the immune system toward fighting tumours in...