A unified approach to meta-selective methylation, mono-, di- and trifluoromethylation of arenes

• DOI: 10.1039/d5sc01367d
• Publication Date: 2025-04-10T15:20:35Z
• Authors: Elisa Y. Lai; Lutz Ackermann; Magnus J. Johansson
• Keywords: Trifluoromethylation

Introducing C 1 aliphatic motifs, including methyl, mono-, di-, and trifluoromethyl groups, to arenes at meta -position can be achieved by a ruthenium-catalyzed C–H functionalization decarboxylative sequence.