Long noncoding RNA ILF3-AS1 promotes cell proliferation, migration, and invasion via negatively regulating miR-200b/a/429 in melanoma

• DOI: 10.1042/bsr20171031
• Publication Date: 2017-09-22T00:10:33Z
• Authors: Xiangjun Chen; Sha Liu; Xiaochun Zhao; Xiao Ma; Guozhen Gao; Li Yu; Dexiong Yan; Hao Dong; Weijing Sun
• Keywords: 0303 health sciences; Skin Neoplasms; Prognosis; Survival Analysis; 3. Good health; Gene Expression Regulation, Neoplastic; MicroRNAs; 03 medical and health sciences; Cell Movement; Cell Line, Tumor; Humans; Melanocytes; Enhancer of Zeste Homolog 2 Protein; RNA, Long Noncoding; RNA, Small Interfering; Promoter Regions, Genetic; Melanoma; Research Articles; Cell Proliferation; Signal Transduction

Melanoma is the most malignant skin cancer, which account for of skin-cancer-related deaths. Long noncoding RNA (lncRNA) a class RNAs with crucial roles in many cancers. However, lncRNAs melanoma have not been well studied. In present study, using public available data and clinical tissues samples, we found that lncRNA ILF3-AS1 up-regulated cell lines, correlated poor prognosis patients. Functional experiments showed knockdown inhibits proliferation, migration, invasion. Mechanistically, interacts EZH2, promotes binding EZH2 to miR-200b/a/429 promoter, represses expression. The expression negatively tissues. Moreover, inhibition abrogates biological on conclusion, these results demonstrate melanoma-upregulated invasion via regulating miR-200b/a/429, imply may be potential prognostic biomarker therapeutic target melanoma.