Negative regulation of leucocyte functions by CD33-related siglecs

• DOI: 10.1042/bst0341024
• Publication Date: 2006-11-03T12:24:03Z
• Authors: T. Avril; H. Attrill; J. Zhang; A. Raper; P.R. Crocker
• Keywords: SIGLEC

The siglecs (sialic acid-binding Ig-like lectins) are a family of transmembrane receptors expressed in the haemopoietic, immune and nervous systems. CD33-related distinct subset mostly innate system where they can function as inhibitory by suppressing signalling mediated coupled with ITAMs (immunoreceptor tyrosine-based activation motifs). contain ITIMs motifs) that recruit activate SHP-1 [SH2 (Src homology 2) domain-containing phosphatase-1] SHP-2. In addition, suppress siglec-dependent adhesion sialylated ligands mediate endocytosis. Siglec-H is recently characterized murine endocytic receptor lacks intrinsic motifs selectively on PDCs (plasmacytoid dendritic cells). depends DAP12 (DNAX-activating protein 12 kDa) for surface expression cross-linking anti-siglec-H antibodies inhibit interferon-α production following TLR9 (Toll-like 9) ligation. Thus able to diverse functions leucocytes via both ITIM-dependent -independent pathways.