The emerging roles of autophagy in intestinal epithelial cells and its links to inflammatory bowel disease

• DOI: 10.1042/bst20221300
• Publication Date: 2023-04-13T11:11:56Z
• Authors: Sharon Tran; Juliani Juliani; W. Douglas Fairlie; Erinna F. Lee
• Keywords: ATG16L1; Intestinal epithelium

Landmark genome-wide association studies (GWAS) identified that mutations in autophagy genes correlated with inflammatory bowel disease (IBD), a heterogenous characterised by prolonged inflammation of the gastrointestinal tract, can reduce person's quality life. Autophagy, delivery intracellular components to lysosome for degradation, is critical cellular housekeeping process removes damaged proteins and turns over organelles, recycling their amino acids other constituents supply cells energy necessary building blocks. This occurs under both basal challenging conditions such as nutrient deprivation. An understanding relationship between autophagy, intestinal health IBD aetiology has improved time, having verified role epithelium immune cells. Here, we discuss research led an genes, including ATG16L, ATG5, ATG7, IRGM, Class III PI3K complex members, contribute innate defence epithelial (IECs) via selective bacteria (xenophagy), how contributes regulation barrier cell junctional proteins, secretory subpopulations, namely Paneth goblet We also stem utilise autophagy. Importantly, mouse have provided evidence deregulation serious physiological consequences IEC death inflammation. Thus, now established key regulator homeostasis. Further into its cytoprotective mechanisms prevent may provide insights effective management IBD.