Caffeine: Its Effect on Catecholamines and Metabolism in Lean and Obese Humans

• DOI: 10.1042/cs0600527
• Publication Date: 2015-08-07T10:37:56Z
• Authors: R. T. Jung; P. S. Shetty; W. P. T. James; M. A. Barrand; B. A. Callingham
• Keywords: Adult; Blood Glucose; Glycerol; 0301 basic medicine; 2. Zero hunger; Fatty Acids, Nonesterified; Propranolol; 3. Good health; 03 medical and health sciences; Catecholamines; Caffeine; Humans; Insulin; Female; Obesity; Body Temperature Regulation

1. The metabolic response of lean and obese women to caffeine was studied see if could be used demonstrate the subnormal thermogenesis in obesity previously shown after standard meals or intravenous infusions noradrenaline. 2. rise resting rate with similar groups β-adrenoceptor blockade did not reduce increment either group. These responses not, therefore, correspond other thermogenic constitutionally obese. 3. In a post-obese group, i.e. who were now normal weight, there reduced caffeine. 4. Monitoring plasma substrate concentrations showed that change oxygen uptake corresponded changes free fatty acids, so adults effects seem mediated by increases adipocyte lipolysis. This effect seems mainly independent adrenergic system.