Administration of albumin to patients with sepsis syndrome: a possible beneficial role in plasma thiol repletion

• DOI: 10.1042/cs0950459
• Publication Date: 2015-08-07T11:40:53Z
• Authors: Gregory J. QUINLAN; Michael P. MARGARSON; Sharon MUMBY; Timothy W. EVANS; John M. C. GUTTER...
• Keywords: Thiol; Serum Albumin

1.Albumin is often administered intravenously to critically ill patients as a volume expander, combat hypoalbuminaemia, and decrease hyperbilirubinaemia. There is, however, an ongoing debate concerning the therapeutic benefit of former which expensive form treatment. 2.Albumin has several biological functions, in particular ligand binder. It also acts extracellular transition metal ion-binding radical-scavenging antioxidant. These functions are influenced by presence exposed thiol group (cys 34) on surface albumin molecule. 3.The ability infused influence plasma pool, hence antioxidant potential, was investigated with sepsis syndrome. 4.Plasma levels rose rapidly after infusion remained elevated even had declined significantly, due interstitial leakage. Data suggestive some exchange these between molecules containing oxidized groups. 5.Administration syndrome leads sustained increase thiols. Thiols have important repletion patients, who known suffer from oxidative stress, may beneficial effects. Antioxidant represent facet clinically albumin.