Correlation of the adipocyte-derived protein adiponectin with insulin resistance index and serum high-density lipoprotein-cholesterol, independent of body mass index, in the Japanese population

• DOI: 10.1042/cs1030137
• Publication Date: 2015-08-07T11:43:51Z
• Authors: Yukihiro YAMAMOTO; Hiroshi HIROSE; Ikuo SAITO; Motowo TOMITA; Matsuo TANIYAMA; Koichi MATSUBARA; Yasunori OKAZAKI; Tatsuya ISHII; Kanako NISHIKAI; Takao SARUTA
• Keywords: High-density lipoprotein

Adiponectin, which is secreted specifically by adipose tissue, has been shown to act as an anti-atherosclerotic protein direct effects on endothelial cells. Clinical studies have that adiponectin levels are lower in individuals with obesity, diabetes and coronary artery disease. The present study investigated relationships between serum body mass index (BMI), blood pressure, insulin resistance index, lipid profile, uric acid high-sensitivity C-reactive a large number of Japanese subjects not taking any medication for metabolic disease without severe illness (705 men 262 women; age 30–65 years; BMI 22.5±2.9kg/m2). concentration was measured ELISA, protein-denaturing step. assessed homoeostasis model assessment (HOMA-IR). women (13.5±7.9μg/ml) significantly higher than (7.2±4.6μg/ml). level negatively correlated BMI, systolic diastolic fasting plasma glucose, insulin, HOMA-IR, total cholesterol, triacylglycerols, low-density lipoprotein (LDL)-cholesterol acid, positively high-density (HDL)-cholesterol. correlations HDL-cholesterol, LDL-cholesterol were significant even after adjustment age, sex BMI. Stepwise multiple regression analysis revealed sex, HOMA-IR independently the (R2 = 0.377). These findings suggest independent population.