Association of putative functional variants in the PLAU gene and the PLAUR gene with myocardial infarction

• DOI: 10.1042/cs20100151
• Publication Date: 2010-06-03T11:03:26Z
• Authors: Jing Xu; Wenlong Li; Xunna Bao; Hu Ding; Jingzhou Chen; Weili Zhang; Kai Sun; Jizheng Wang; Xiaojian Wang; Hu Wang; Hui Yu; Weihua Song; Weiwei Ma; Lin Zhang; Changxin Wang; Daowen Wang; Rutai Hui
• Keywords: Pathogenesis

uPA (urokinase-plasminogen activator) and its receptor (uPAR) have been implicated in a broad spectrum of pathophysiological processes, including fibrinolysis, proteolysis, inflammation, atherogenesis plaque destabilization, all which are involved the pathogenesis MI (myocardial infarction). We hypothesized that putative functional genetic variation two genes encoding uPAR (PLAU PLAUR respectively) might influence susceptibility to MI. genotyped rs4065 [3'-UTR (untranslated region) *141C>T) rs2227564 (Pro141Leu) PLAU gene as well rs344781 (-516T>C) 633 patients 1237 gender- age-matched control subjects. Our results showed T allele was significantly associated with an increased risk MI, adjusted OR (odds ratio) 1.38 [95% CI (confidence interval), 1.07-1.78; P=0.012) under dominant model, 1.4 (95% CI, 1.12-1.75; P=0.003) additive model 2.5 1.15-5.41; P=0.02) recessive model. The findings were then replicated another independent case-control study 545 597 In conclusion, our suggest be previously unknown factor for Chinese Han population.