JAM-A promotes wound healing by enhancing both homing and secretory activities of mesenchymal stem cells

• DOI: 10.1042/cs20140735
• Publication Date: 2015-05-22T14:04:09Z
• Authors: Minjuan Wu; Shizhao Ji; Shichu Xiao; Zhengdong Kong; He Fang; Yunqing Zhang; Kaihong Ji; Yongjun Zheng; Houqi Liu; Zhaofan Xia
• Keywords: Homing (biology)

The homing ability and secretory function of mesenchymal stem cells (MSCs) are key factors that influence cell involvement in wound repair. These controlled by multilayer regulatory circuitry, including adhesion molecules, core transcription (TFs) certain other regulators. However, the role molecules this circuitry their underlying mechanism remain undefined. In present paper, we demonstrate an molecule, junction molecule A (JAM-A), may as a promoter to regulate skin healing MSCs. vivo experiments, show JAM-A up-regulation promoted both MSC full-thickness wounds healing-related cytokine secretion vitro experiments also showed proliferation migration activating T-cell lymphoma invasion metastasis 1 (Tiam1). We suggest can increase proliferation, wound-homing MSCs, thus accelerating repair rate defects. results provide insights into novel potentially effective approach improve efficacy treatment.