ProbioticLactobacillus paracaseiHII01 protects rats against obese-insulin resistance-induced kidney injury and impaired renal organic anion transporter 3 function

• DOI: 10.1042/cs20180148
• Publication Date: 2018-07-06T13:45:58Z
• Authors: Keerati Wanchai; Sakawdaurn Yasom; Wannipa Tunapong; Titikorn Chunchai; Sathima Eaimworaw...; Parameth Thiennimitr; Chaiyavat Chaiyasut; Anchalee Pongchai...; Varanuj Chatsudth...; Siriporn Chattipa...; Nipon Chattipakorn; Anusorn Lungkaphin
• Keywords: Lactobacillus paracasei

The relationship between gut dysbiosis and obesity is currently acknowledged to be a health topic which causes low-grade systemic inflammation insulin resistance may damage the kidney. Organic anion transporter 3 (Oat3) has been shown as responsible for renal handling of microbiota products are involved in progression metabolic disorder. present study investigated effect probiotic supplementation on kidney function, Oat3 inflammation, endoplasmic reticulum (ER) stress, apoptosis obese, insulin-resistant rats. After 12 weeks being provided with either normal or high-fat diet (HF), rats were divided into (ND); ND treated probiotics (NDL); HF; HF (HFL). Lactobacillus paracasei HII01 1 × 108 colony forming unit (CFU)/ml was administered daily by oral gavage weeks. Obese showed significant increases serum lipopolysaccharide (LPS), plasma lipid profiles, resistance. Renal Oat function decreased along dysfunction HF-fed also demonstrated ER apoptosis, gluconeogenesis kidneys. These alterations improved treatment. In conclusion, alleviated leading obese benefits involve attenuation hyperlipidemia, suggested idea remote sensing signaling system might facilitate through improvement function.