A protective role of renalase in diabetic nephropathy

• DOI: 10.1042/cs20190995
• Publication Date: 2020-01-03T11:33:56Z
• Authors: Jianyong Yin; Xuanchen Liu; Ting Zhao; Rulian Liang; Rui Wu; Fangfei Zhang; Yiwei Kong; Limei Liu; Tao Xing; Niansong Wang; Qing Zhao; Feng Wang
• Keywords: Mice, Knockout; 0301 basic medicine; 0303 health sciences; Kidney; Diabetes Mellitus, Experimental; 3. Good health; Disease Models, Animal; 03 medical and health sciences; Mesangial Cells; Albuminuria; Animals; Humans; Diabetic Nephropathies; Monoamine Oxidase

Abstract Renalase, a recently discovered secreted flavoprotein, exerts anti-apoptotic and anti-inflammatory effects against renal injury in acute chronic animal models. However, whether Renalase elicits similar the development of diabetic nephropathy (DN) remains unclear. The studies presented here tested hypothesis that may play key role DN have therapeutic potential for DN. expression was measured human kidney biopsies with kidneys db/db mice. examined using genetically engineered mouse model: knockout mice background. renoprotective evaluated overexpression. In addition, on high glucose-induced mesangial cells were investigated. down-regulated compared healthy controls or db/m homozygous increased arterial blood pressure significantly while heterozygous did not. resulted elevated albuminuria expansion Mesangial hypertrophy, inflammation, pathological exacerbated wild-type littermates. Moreover, overexpression ameliorated Mechanistically, attenuated profibrotic gene p21 through inhibiting extracellular regulated protein kinases (ERK1/2). present study suggested protected progression might be novel target treatment