Transplantation of platelet-derived mitochondria alleviates cognitive impairment and mitochondrial dysfunction in db/db mice

• DOI: 10.1042/cs20200530
• Publication Date: 2020-08-14T14:59:05Z
• Authors: Hongli Ma; Tao Jiang; Wenxin Tang; Zhi Ma; Kairui Pu; Fuxing Xu; Haiqing Chang; Ge Zhao; Wei Gao; Yansong Li; Qiang Wang
• Keywords: Venipuncture

Abstract Diabetes-associated cognitive impairment (DACI) can increase the risk of major cardiovascular events and death. Neuronal functionality is highly dependent on mitochondria emerging evidence has shown that mitochondrial transplantation a potential effective strategy reduce brain injury associated disorders. Platelets are abundant in blood be considered readily available source small-size mitochondria. These cells easily acquired from peripheral with minimal invasion via simple venipuncture. The present study aimed to investigate whether platelet-derived (Mito-Plt) could improve DACI. Cognitive behaviors were assessed using Morris water maze test db/db mice. results demonstrated Mito-Plt was internalized into hippocampal neurons 24 h following intracerebroventricular injection. Importantly, one month transplantation, DACI alleviated mice effect accompanied increased number, restored function, attenuated oxidative stress neuronal apoptosis, as well decreased accumulation Aβ Tau hippocampus. Taken together, data dysfunction This method may therapeutic application for treatment