The effect of testosterone replacement treatment on immunological features of patients with Klinefelter's syndrome

• DOI: 10.1046/j.1365-2249.2000.01329.x
• Publication Date: 2003-03-11T10:23:20Z
• Authors: I H Koçar; Z Yesilova; M Özata; M Turan; A Sengül; I Ç Özdemir
• Keywords: Klinefelter syndrome; Nephelometry; Androgen Deficiency; Cellular immunity; Humoral immunity

SUMMARY Although the effects of androgen deficiency in immune system have long been appreciated, little is known about immunological features patients with Klinefelter's syndrome (KS). On other hand, interest androgens as a possible treatment for some autoimmune diseases growing. In present study, parameters were evaluated 26 KS prior to replacement (ART) and results compared those 19 healthy control subjects. Patients then treated testosterone 6 months pre- post-treatment findings compared. Serum levels IgG, IgA, IgM, C3c C4 measured by nephelometry lymphocyte subsets CD4+/CD8+ ratios examined flow cytometry. IL-2 IL-4 ELISA. Pretreatment serum higher than controls all decreased significantly following ART. The pretreatment absolute numbers percentages CD3+, CD4+, CD19+ cells Percentages CD8+ increased significantly, while C3 both after It concluded that lack enhances cellular humoral immunity ART may suppress this.