Beta cell function declines with age in glucose tolerant Caucasians

• DOI: 10.1046/j.1365-2265.2000.01132.x
• Publication Date: 2003-03-11T10:47:02Z
• Authors: Ken C. Chiu; Nancy P. Lee; Pejman Cohan; Lee‐Ming Chuang
• Keywords: Waist–hip ratio

OBJECTIVE As type 2 diabetes results from an imbalance between insulin sensitivity and beta cell function, either or both may worsen with age. However, existing data are controversial on the effect of ageing function. SUBJECTS AND DESIGN We enrolled 149 healthy, glucose tolerant normotensive Caucasians (age 35 ± 1 years, body mass index 26.07 0.44 kg/m , waist‐hip ratio 0.842 0.009 cm/cm, mean standard error). A cross‐sectional study was designed to examine impact age Their function (percentage B [%B]) S [%S]) were estimated using homeostasis model assessment. RESULTS Simple regression analysis revealed that %B declined ( P = 0.008) while no relation found %S 0.769). stepwise diastolic blood pressure explained 14.7% variation in %S, age, ratio, gender, systolic had influence %S. Age, together accounted for 21.7% %B, being independent variable. CONCLUSIONS In present study, we showed at a rate about 1% per year. contrast, not affected by ageing. Our observations suggest age‐related decline tolerance is primarily related loss beta‐cell