Renal cell carcinoma with rhabdoid features: an aggressive neoplasm

• DOI: 10.1046/j.1365-2559.2002.01427.x
• Publication Date: 2004-12-25T01:55:35Z
• Authors: K Kuroiwa; Y Kinoshita; H Shiratsuchi; Y Oshiro; S Tamiya; Y Oda; S Naito; M Tsuneyoshi
• Keywords: Neoplasm

Aims: Only a few reports on renal cell carcinoma with rhabdoid features have been published. This study was performed to investigate the clinicopathological characteristics of carcinomas features. Methods and results: Among 253 cases in adults, eight were detected. Rhabdoid areas ranged from 10% 90% each cases. Seven TNM stage III or IV, four died within 8 months surgery. Immunohistochemically, positive for CAM 5.2 (4/8), AE1/AE3 (6/8), epithelial membrane antigen (6/8) vimentin (8/8), negative myogenetic markers (0/8). The mean MIB‐1 labelling index higher than that definite carcinomatous areas. Ultrastructurally, perinuclear whorls intermediate filaments demonstrated three using paraffin‐embedded blocks. Conclusions: histological, immunohistochemical ultrastructural similarities malignant tumours. Renal is highly aggressive neoplasm its behaviour may be due high cell‐proliferative activity represent endpoint clonal evolution (especially clear type cases).