Prevalence of hepatitis B or C virus infections in patients with non‐Hodgkin's lymphoma

• DOI: 10.1046/j.1440-1746.2001.02406.x
• Publication Date: 2003-03-12T05:18:53Z
• Authors: Masami Kuniyoshi; Makoto Nakamuta; Hironori Sakai; Munechika Enjoji; Naoko Kinukawa; Kazuhiro Kotoh; Marie Fukutomi; Masaki Yokota; Hidehiro Nishi; Hiroaki Iwamoto; Naokuni Uike; Junji Nishimura; Shuichi Inaba; Yoshiaki Maeda; Hajime Nawata; Koichiro Muta
• Keywords: Lymphoproliferative Disorders; Hepatitis B

Abstract Background: Hepatitis C virus (HCV) and hepatitis B (HBV) are not only hepatotropic, but also lymphotropic viruses. Recently, some reports suggested that these viruses may participate in the development of malignant lymphoproliferative disorders. Methods: We investigated prevalence HCV or HBV infection 348 patients with non‐Hodgkin's lymphoma (NHL). compared prevalences those blood donors as a control group representing general population our area ( n = 1 513 358). Next, we evaluated clinical pathologic characteristics HCV‐ HBV‐infected NHL cases. Non‐Hodgkin's was classified according to Working Formulation classification. Results: Thirty‐seven cases (14.9%) were found be infected HBV; these, 20 (8.1%) HCV, 17 (6.9%) HBV. In male patients, rate significantly higher than an age‐ sex‐matched same P < 0.001, Mantel– Haenszel test). The tended 0.0551). contrast, female population. HCV‐infected cases, 15 (75%) had B‐cell 16 (80%) being intermediate grade; comprised 83% all 11 (65%) type 10 (58%) grade. Conclusions: high infections study provides epidemiologic evidence suggesting involved subgroup males. Our investigation revealed both showed certain similarities manifestations.