Serological survey of measles and rubella immunity in Sydney preschool children

• DOI: 10.1046/j.1440-1754.2000.00540.x
• Publication Date: 2003-03-12T08:14:51Z
• Authors: J Causer; M Mira; M Karr; L Hueston; M Burgess; G Alperstein; M Fett; A Cunningham
• Keywords: Measles-Mumps-Rubella Vaccine

Objectives : To estimate the prevalence of serological evidence immunity to measles and rubella in preschool children central southern Sydney (NSW, Australia) with either documented or parentally reported immunization. Methods Geographical cluster random sampling was used select aged between 18 60 months participate present study. Standardized interviews obtained information on each child’s (by parents) immunization status documentary recorded from Personal Health Record. Venous blood collected, serum separated stored frozen until tested. Measles antibodies were measured using ELISA, immunofluorescence haemagglutination inhibition being clarify equivocal results. The study conducted 1992 1994 conjunction surveys lead concentrations, iron micronutrient status. Results Parents 726 953 identified 9 age agreed lead, immunization, studies. Sufficient for antibody testing 580 children, 62 at time collection. that 94.7% (95% confidence interval (CI) 92.7–96.5%) had received a measles–mumps measles–mumps–rubella (MMR) General practitioners administered 72.8% these immunizations. 88.8% CI 86.2–91.4%) 91.9% 89.6–94.2%), respectively. There 88.4% 85.7–91.2%) 86.4% 83.4–89.3%) Of 91.6% 89.2–94.0%) detectable antibody. 97.2% 95.8–98.6%) Conclusions rates are relatively high most immunizations provided by private sector. Immunity is level would be expected seroconversion slightly lower than studies, highlighting need second MMR as well making near universal imperative if this disease eradicated.