Oestrogen and progesterone receptor expression in the female lower urinary tract, with reference to oestrogen status

• DOI: 10.1046/j.1464-410x.2000.00724.x
• Publication Date: 2003-03-11T07:55:25Z
• Authors: P.J. Blakeman; P. Hilton; J.N. Bulmer
• Keywords: Progesterone receptor; Oestrogen receptor

Objective To assess the incidence and distribution of both oestrogen progesterone receptors throughout female lower urinary tract, to compare receptor expression in women varying status. Patients methods The study included 90 undergoing surgery for urogynaecological conditions; 33 were premenopausal, 26 postmenopausal taking no supplementation, 31 receiving some form hormone‐replacement therapy. Biopsies taken during from bladder dome, trigone, proximal urethra, distal vagina vesicovaginal fascia region neck. All biopsies routinely fixed processed histopathological assessment, then labelled immunohistochemically with monoclonal antibodies directed against human (NCL‐ERLH2) (NCL‐PGR) receptors. Both assessed epithelial, subepithelial muscle/deeper fascial regions all tissue overall positivity each receptor, by semiquantitative analysis concentration using histochemical scoring tissues. Results Oestrogen consistently detected squamous epithelia absent urothelial tissues tract irrespective status; there was significant variation histological score. Progesterone more variable, being mostly subepithelial, significantly replacement. Conclusion These findings confirm be a target organ action progesterone, shed further light on areas likely respond This may have implications use supplementation treatment disorders women.