Mitochondrial DNA variability in Poles and Russians

• DOI: 10.1046/j.1469-1809.2002.00116.x
• Publication Date: 2003-03-10T11:10:35Z
• Authors: B. A. MALYARCHUK; T. GRZYBOWSKI; M. V. DERENKO; J. CZARNY; M. WOŹNIAK; D. MIŚCICKA‐ŚLIWKA
• Keywords: Haplogroup; Hypervariable region; mtDNA control region; Coding region; Human mitochondrial genetics

Mitochondrial DNA (mtDNA) sequence variation was examined in Poles (from the Pomerania‐Kujawy region; n = 436) and Russians three different regions of European part Russia; 201), for which two hypervariable segments (HVS I HVS II) haplogroup‐specific coding region sites were analyzed. The use mtDNA RFLP analysis made it possible to distinguish parallel mutations that occurred at particular II during evolution. In total, identified 73 nucleotide (17.8%) 31 (7.73%). classification mitochondrial haplotypes revealed presence all major haplogroups, characterized by similar patterns distribution Russians. An control did not reveal any specific combinations unique their subclusters clearly both from neighbouring populations. only exception is a novel subcluster U4a within subhaplogroup U4, defined diagnostic mutation position 310 II. This found common predominantly between (at frequency 2.3% 2.0%, respectively) may therefore have central‐eastern origin.