Diversity of Mitochondrial DNA Lineages in South Siberia

• DOI: 10.1046/j.1469-1809.2003.00035.x
• Publication Date: 2003-08-27T09:40:26Z
• Authors: M. V. Derenko; T. Grzybowski; B. A. Malyarchuk; I. K. Dambueva; G. A. Denisova; J. Czarny; C. M. Dorzhu; V. T. Kakpakov; D. Miścicka‐Śliwka; M. Woźniak; I. A. Zakharov
• Keywords: Haplogroup

To investigate the origin and evolution of aboriginal populations South Siberia, a comprehensive mitochondrial DNA (mtDNA) analysis (HVR1 sequencing combined with RFLP typing) 480 individuals, representing seven Altaic-speaking (Altaians, Khakassians, Buryats, Sojots, Tuvinians, Todjins Tofalars), was performed. Additionally, HVR2 sequence information obtained for 110 Altaians, providing, in particular, some novel details East Asian mtDNA phylogeny. The total sample revealed 81% (M*, M7, M8, M9, M10, C, D, G, Z, A, B, F, N9a, Y) 17% West Eurasian (H, U, J, T, I, N1a, X) matrilineal genetic contribution, but regional differences within Siberia. highest influx mtDNAs observed from Sayan Altai regions (from 12.5% to 34.5%), whereas Baikal region this contribution markedly lower (less than 10%). considerable substructure Siberian haplogroups together high degree haplogroup C D diversity there, allows us conclude that Siberians carry imprint early-colonization phase Eurasia. Statistical analyses contain levels heterogeneity sequences among (Fst = 5.05%) might be due geography not language anthropological features.