cDNA array reveals differential gene expression following chronic neuroleptic administration: implications of synapsin II in haloperidol treatment

• DOI: 10.1046/j.1471-4159.2002.01104.x
• Publication Date: 2003-03-12T07:02:20Z
• Authors: Victor Z. Chong; L. Trevor Young; Ram K. Mishra
• Keywords: Synapsin I; Synapsin

Abstract The cDNA expression array is a recently developed scientific tool that can profile the differential of several hundreds genes simultaneously and therefore advantageous in study antipsychotic drug action at genetic level. Using this technology, we discovered 14 rat striatum whose was changed by ≥ 50% following chronic haloperidol treatment. Among them synapsin II gene, which found to be significantly up‐regulated after Since recent studies have implicated gene schizophrenia, further experiments were performed determine whether exposure resulted concurrent increases striatal protein. Immunoblotting revealed protein levels both b isoforms also increased comparable amounts This first show regulation transcript level striatum. A possible mechanism for observed haloperidol‐induced increase expression, along with implications up‐regulation treatment, presented.